Type IV filament

The type IV filament (TFF or T4F) is a superfamily of fibrous protein structures assembled in Prokaryotes by machineries that include a set of four evolutionarily related proteins[1]: the eponymous type IV pilin, a prepilin peptidase, an AAA+ ATPase, and an integral cytoplasmic membrane platform.[2]

The TFF superfamily seems to have originated in the last universal common ancestor, from where it diversified into archaella, different type IV pili subtypes, and type II secretion systems.[2]

References

  1. ^ Berry JL, Pelicic V (January 2015). "Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives". FEMS Microbiology Reviews. 39 (1): 134–54. doi:10.1093/femsre/fuu001. PMC 4471445. PMID 25793961.
  2. ^ a b Denise R, Abby SS, Rocha EP (July 2019). "Diversification of the type IV filament superfamily into machines for adhesion, protein secretion, DNA uptake, and motility". PLOS Biology. 17 (7) e3000390. doi:10.1371/journal.pbio.3000390. PMC 6668835. PMID 31323028.
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