Nuclear atypia

Micrograph showing extreme nuclear atypia in cancer (glioblastoma). Brain biopsy. HPS stain.
Cytopathology of reactive urothelial changes, Pap stain, showing urothelial cells with enlarged nuclei but a nucleus-cytoplasm ratio of less than 0.5. There are bacteria, as well as an inflammatory response of neutrophils, providing a cause for the changes.

Nuclear atypia refers to abnormal appearance of cell nuclei.[1] It is a term used in cytopathology and histopathology. Atypical nuclei are often pleomorphic.

Nuclear atypia can be seen in reactive changes, pre-neoplastic changes,[1] and malignancy. Severe nuclear atypia is, in most cases, considered an indicator of malignancy.

See also

References

  1. ^ a b Schwab, Manfred, ed. (2011-10-14). "Nuclear Atypia". Encyclopedia of Cancer. Springer Science & Business Media. ISBN 978-3-642-16482-8.
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