Dimethylglycine oxidase
| Dimethylglycine oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.5.3.10 | ||||||||
| CAS no. | 74870-79-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Dimethylglycine oxidase (EC 1.5.3.10) is an enzyme that catalyzes the chemical reaction
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The three substrates of this enzyme are dimethylglycine, water and oxygen. Its products are sarcosine, hydrogen peroxide, and formaldehyde.[1] The enzyme does not further demethylate the product sarcosine to glycine.[2] Enzymes such as sarcosine oxidase are known which can do that conversion.[3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N,N-dimethylglycine:oxygen oxidoreductase (demethylating). It employs one cofactor, FAD.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1PJ5, 1PJ6, and 1PJ7.
References
- ^ Enzyme 1.5.3.10 at KEGG Pathway Database.
- ^ Mori, Nobuhiro; Kawakami, Bunsei; Tani, Yoshiki; Yamada, Hideaki (1980). "Purification and properties of dimethylglycine oxidase from Cylindrocarpon didymum M-1". Agricultural and Biological Chemistry. 44 (6): 1383–1389. doi:10.1271/bbb1961.44.1383.
- ^ Suzuki, H. (1994). "Sarcosine oxidase: Structure, function, and the application to creatinine determination". Amino Acids. 7 (1): 27–43. doi:10.1007/BF00808444. PMID 24185971.