DIPK1B

DIPK1B
Identifiers
AliasesDIPK1B, C9orf136, pp6977, family with sequence similarity 69 member B, divergent protein kinase domain 1B, FAM69B
External IDsOMIM: 614543; MGI: 1927576; HomoloGene: 10516; GeneCards: DIPK1B; OMA:DIPK1B - orthologs
Orthologs
SpeciesHumanMouse
Entrez

138311

56279

Ensembl

ENSG00000165716

ENSMUSG00000036186

UniProt

Q5VUD6

Q99ML4

RefSeq (mRNA)

NM_152421

NM_019833

RefSeq (protein)

NP_689634

NP_062807

Location (UCSC)Chr 9: 136.71 – 136.72 MbChr 2: 26.52 – 26.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DIPK1B or divergent protein kinase domain 1B is a protein that in humans is coded by the DIPK1B gene.[5] It is a member of the FAM69 family, which consists of three members across all vertebrates other than fish. Is is also known as FAM69B.[6]

Gene

DIPK1B and its surrounding genes on Chromosome 9.

The DIPK1B gene is found on human chromosome 9, in the 9q34.3 band.[6] The gene is located on the plus strand and spans 12,275 bases.[7] The gene contains five exons. It is a member of FAM69, a family of genes with three members, DIPK1A, DIPK1B, and DIPK1C.[8] This family is present in all vertebrates, with slight differences in fish, and orthologs of highly conserved structure are found in all metazoa.[8]

Transcripts

DIPK1B Protein with notated post-translational modifications and domains.

In humans there is only one known DIPK1B transcript. The mRNA transcript of DIPK1B is 2358 bases long, and contains all five exons of the DIPK1B gene.[9]

Protein

Structure of DIPK1B determined by AlphaFold [10] and annotated in iCn3D[11]. The transmembrane domain is shown in green and the protein kinase domain in white. Predicted disulfide bonds are shown in yellow.

Human DIPK1B has only one isoform. The resultant protein is 431 amino acids long, has an isoelectric point of 9, and has a predicted molecular weight of 48.6 kDa.[5][12] DIPK1B contains two distinct domains, a transmembrane domain and a protein kinase domain.[5]

Expression

DIPK1B exhibits variable ubiquitous expression at moderate to high levels.[13] Expression in the brain, heart, and lung is notably higher than in other tissues.[6]

Regulation

DIPK1B is localized to the membrane of the endoplasmic reticulum.[8] It is expected to undergo a number of post-translational modifications, including o-linked glycosylation, phosphorylation, ubiquitination, and acetylation.[14]

Homology

DIPK1B Orthologs
Genus and Species Common Name Taxonomic Group Date of Divergence (MYA) Accession Number Sequence Length (aa) Sequence Identity to Human Protein (%) Sequence Similarity to Human Protein (%)
Homo sapiens Humans Primates 0 NP_689634 431 100 100
Gorilla gorilla gorilla Gorilla Primates 8.6 XP_004048941.2 431 99.5 99.5
Desmodus rotundus Vampire bat Mammals 94 XP_053775135 435 84.9 90.7
Dromiciops gliroides Monito del monte Marsupials 160 XP_043845610.1 431 71.2 83.5
Gopherus flavomarginatus Bolson tortoise Reptiles 319 XP_050782714.1 431 68.2 82.6
Tiliqua scincoides Common blue-tongued skink Reptiles 319 XP_066466737.1 431 66.8 81.4
Varanus komodoensis Komodo dragon Reptiles 319 XP_044309118.1 431 65.7 90
Cyrtonyx montezumae Montezuma quail Birds 319 XP_065593300.1 431 67.5 82.6
Gallus gallus Chicken Birds 319 XP_415423 431 67.3 82.4
Taeniopygia guttata Australian zebra finch Birds 319 XP_002199526.4 431 66.1 81.7
Geothlypis trichas Common yellowthroat Birds 319 KAL9827061.1 431 65.9 82.4
Ambystoma mexicanum Axolotl Amphibians 352 XP_069465698.1 431 67.5 81
Ascaphus truei Tailed Frog Amphibians 352 XP_075435024 431 66.1 82.6
Xenopus laevis African clawed frog Amphibians 352 XP_018088073.1 431 62.9 80.3
Protopterus annectens West African Lungfish Fish 408 XP_043914470 431 65.4 82.4
Hypanus sabinus Atlantic stingray Fish 462 XP_059850265.1 431 61.5 80.3
Callorhinchus milii Australian ghostshark Fish 462 XP_042193771.1 431 60.8 78.4
Amblyraja radiata Thorny skate Fish 462 XP_032904599 431 58.9 79.1
Magallana gigas Pacific Oyster Mollusks 686 XP_011453093.2 438 23.7 40
Anopheles gambiae Mosquito Insects 686 XP_061498526 427 23 37.3

Function

DIPK1B has been shown to interact with SAT1 and SLC39A12.[15]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165716 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036186 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "NCBI Protein - divergent protein kinase domain 1B [Homo sapiens]". www.ncbi.nlm.nih.gov. Retrieved 2025-12-04.
  6. ^ a b c "NCBI Gene - DIPK1B divergent protein kinase domain 1B [Homo sapiens (human)]". www.ncbi.nlm.nih.gov. Retrieved 2025-12-04.
  7. ^ "GeneCards- DIPK1B Gene". Retrieved 2025-09-08.
  8. ^ a b c Tennant-Eyles AJ, Moffitt H, Whitehouse CA, Roberts RG (March 2011). "Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins". Biochemical and Biophysical Research Communications. 406 (3): 471–477. Bibcode:2011BBRC..406..471T. doi:10.1016/j.bbrc.2011.02.076. PMID 21334309.
  9. ^ "NCBI Nuccore - Homo sapiens divergent protein kinase domain 1B (DIPK1B), mRNA". 27 April 2025. Retrieved 2025-09-08.
  10. ^ "AlphaFold Protein Structure Database". alphafold.ebi.ac.uk. Retrieved 2025-12-04.
  11. ^ "iCn3D: Web-based 3D Structure Viewer". www.ncbi.nlm.nih.gov. Retrieved 2025-12-04.
  12. ^ "Expasy - Compute pI/Mw tool". web.expasy.org. Retrieved 2025-12-04.
  13. ^ "GDS3113 / 137763". www.ncbi.nlm.nih.gov. Retrieved 2025-12-04.
  14. ^ "DIPK1B (human)". www.phosphosite.org. Retrieved 2025-12-04.
  15. ^ "IntAct Portal". www.ebi.ac.uk. Retrieved 2025-12-12.
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